AtovaquoneProguanil Hydrochloride 250 mg100 mg Film ... | 全球疫情雷達
![AtovaquoneProguanil Hydrochloride 250 mg100 mg Film ...](https://i.imgur.com/7bk9Rso.jpg)
Atovaquoneisahighlylipophiliccompoundwithlowaqueoussolubility.InHIV-infectedpatients,theabsolutebioavailabilityofa750mgsingledoseof ...
![AtovaquoneProguanil Hydrochloride 250 mg100 mg Film ...](https://i.imgur.com/7bk9Rso.jpg)
There are no pharmacokinetic interactions between atovaquone and proguanil at the recommended dose.
Absorption
Atovaquone is a highly lipophilic compound with low aqueous solubility. In HIV-infected patients, the absolute bioavailability of a 750 mg single dose of atovaquone tablets taken with food is 23% with an inter-subject variability of about 45%.
Dietary fat taken with atovaquone increases the rate and extent of absorption, increasing AUC 2-3 times and Cmax 5 times over fasting. Patients are recommended to take Atovaquone/Proguanil Hydrochloride with food or a milky drink (see section 4.2).
Proguanil hydrochloride is rapidly and extensively absorbed regardless of food intake.
Distribution
Apparent volume of distribution of atovaquone and proguanil is a function of bodyweight.
Atovaquone is highly protein boun...
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